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Modified HGH Fragment
Fat Metabolism Without IGF-1: The Isolated Lipolytic Domain
AOD-9604 is a modified 16-amino-acid C-terminal fragment of human growth hormone (Tyr-hGH 177-191) with a stabilizing disulfide bridge. Unlike full HGH, AOD-9604 retains only the lipolytic domain — stimulating fat breakdown and inhibiting lipogenesis without affecting IGF-1 levels or glucose tolerance. Phase 2b trials in 300 obese individuals showed the peptide tripled weight loss compared to placebo with a safety profile indistinguishable from placebo.
- 16-amino-acid fragment: Tyr-hGH 177-191 with disulfide bridge
- Stimulates lipolysis (fat breakdown)
- Inhibits lipogenesis (fat storage)
- No meaningful IGF-1 elevation
- Placebo-like safety profile in human trials
For laboratory research use only. Not for human consumption.
Multi-Pathway Mechanism
How AOD-9604 Achieves Fat Loss Without HGH Side Effects
AOD-9604 was originally thought to work exclusively via β3-adrenergic receptors on white adipose tissue. However, research in β3-AR knockout mice revealed fat loss still occurs — indicating at least two distinct mechanisms. The secondary pathway may involve direct induction of apoptosis in white fat cells. This dual-mechanism approach explains the peptide's robust efficacy while maintaining metabolic safety — no antibody formation, no insulin resistance, no glucose intolerance.
- β3-adrenergic receptor activation (shifts fat to "usage mode")
- Secondary pathway: Possible adipocyte apoptosis induction
- Works even in β3-AR knockout models
- No antibody formation (structural similarity to HGH)
- No insulin resistance or glucose intolerance
For laboratory research use only. Not for human consumption.
Expanding Research Applications
From Obesity to Joint Repair and Cardiovascular Protection
Beyond fat metabolism, AOD-9604 research has expanded into unexpected territories. Intra-articular injections show synergistic effects with hyaluronic acid in osteoarthritis models — improving pain, disability, and cartilage structure at both gross and microscopic levels. Cardiovascular research suggests the peptide may improve metabolic markers beyond its obesity effects, similar to pioglitazone and acipimox — potentially through the same secondary pathway that enables β3-AR-independent fat loss.
- Obesity: Tripled weight loss vs placebo in Phase 2b
- Osteoarthritis: Synergy with hyaluronic acid, cartilage improvement
- Cardiovascular: Metabolic benefits beyond fat reduction
- Steady weight loss rate (no resistance development)
- Novel cartilage growth pathway research
For laboratory research use only. Not for human consumption.
The Science Behind Targeted Fat Metabolism: Why AOD-9604 Isolates What Matters
AOD-9604 represents an elegant approach to fat metabolism research. By isolating the C-terminal lipolytic domain of human growth hormone (amino acids 177-191) and adding a stabilizing disulfide bridge, researchers created a peptide that retains HGH's fat-burning properties while eliminating its effects on IGF-1, insulin sensitivity, and glucose tolerance. This selective profile enables metabolic research impossible with full HGH.
The clinical evidence is substantial. Phase 2b trials in Australia tested AOD-9604 in 300 obese individuals over 12 weeks. Results showed the peptide tripled weight loss compared to placebo, with weight loss rates remaining steady throughout — indicating no resistance development and suggesting longer protocols would yield greater results. Safety was indistinguishable from placebo across six human studies including both IV and oral administration.
Mechanistically, AOD-9604 operates through at least two pathways. The primary mechanism involves β3-adrenergic receptor activation on white adipose tissue, shifting fat cells from storage to utilization mode. However, research in β3-AR knockout mice revealed fat loss still occurs — confirming a secondary mechanism, potentially involving direct adipocyte apoptosis. This dual-pathway approach may explain the peptide's robust efficacy.
Research applications have expanded beyond obesity. Intra-articular AOD-9604 injections show synergistic effects with hyaluronic acid in osteoarthritis models, improving pain scores and cartilage structure at both gross and microscopic levels — a finding relevant to the challenging problem of cartilage regeneration. Cardiovascular research suggests metabolic benefits beyond weight loss. For teams investigating fat metabolism, metabolic syndrome, osteoarthritis, or cardiovascular risk, AOD-9604 provides a uniquely targeted tool with extensive human safety data.
For research use only. Not for human consumption.
Scientific References
- Heffernan MA, et al. Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment. Int J Obes Relat Metab Disord. 2001;25(10):1442-1449.
- Heffernan MA, et al. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology. 2001;142(12):5182-5189.
- Heffernan MA, et al. Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism. Am J Physiol Endocrinol Metab. 2000;279(3):E501-E507.
- Kwon DR, et al. Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Ann Clin Lab Sci. 2015;45(4):426-432.
CERTIFICATE
A detailed summary of the analytical profile, purity, and molecular integrity of the research-grade peptide compound.
Each vial contains a highly purified lyophilized peptide, produced under sterile laboratory conditions and tested for >99% purity via HPLC and mass spectrometry.
Formulated without additives or fillers, our peptides are ideal for cutting-edge scientific research in areas such as cellular mechanisms, tissue regeneration, and metabolic modulation.
For research use only. Not intended for human or veterinary use.
Each batch undergoes rigorous third-party testing to ensure molecular accuracy, sterility, and stability. Our commitment to scientific precision guarantees that every vial reflects the highest standards of quality control and consistency, making them ideal for reproducible and reliable research outcomes.
DIRECTIONS
All peptides are supplied in lyophilized powder form for research use only. Not intended for human or veterinary use.
Use Bacteriostatic Water (0.9%).
Slowly inject the liquid along the inner wall of the vial using a sterile syringe.
Do not shake. Swirl gently until the powder dissolves completely.
Recommended volume depends on your lab protocol (commonly 1–2 mL).
- : Keep lyophilized peptide at 36–46°F, or frozen (-4°F) for long-term stability.
- : Store in the refrigerator (36–46°F) and use within 10 to 30 days, depending on the peptide.
These compounds are intended for Research Use Only.
Always wear gloves and sterile lab gear.
Avoid contamination. Use clean tools and surfaces.
Dispose of all biological materials, including syringes and empty vials, according to your local laboratory safety regulations.
COMPOSITION
An overview of the research characteristics and integrity of the peptide compound.
Each vial contains a highly purified lyophilized peptide, produced under sterile laboratory conditions and tested for >99% purity via HPLC and mass spectrometry.
Formulated without additives or fillers, our peptides are ideal for cutting-edge scientific research in areas such as cellular mechanisms, tissue regeneration, and metabolic modulation.
For research use only. Not intended for human or veterinary use.
Each batch undergoes rigorous third-party testing to ensure molecular accuracy, sterility, and stability. Our commitment to scientific precision guarantees that every vial reflects the highest standards of quality control and consistency, making them ideal for reproducible and reliable research outcomes.
Peptides are shipped as lyophilized powder to ensure maximum stability. Upon arrival, store at -4°F in a dry, dark environment. Once reconstituted, use promptly or refrigerate at 36–46°F for short-term stability. Proper storage preserves biological integrity and ensures reliable research performance over time.
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Tirzepatide – 30mg
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Peptidic.Peptide Sciences
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$108.00$275.00
- ≥99.784%98–99.3%
- 30 mg15 mg
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